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Cardiff Oncology Reports First Patient Dosing in P-II Trial for Onvansertib + Irinotecan and 5-FU as a 2L Treatment for Metastatic Pancreatic Ductal Adenocarcinoma

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Cardiff Oncology Reports First Patient Dosing in P-II Trial for Onvansertib + Irinotecan and 5-FU as a 2L Treatment for Metastatic Pancreatic Ductal Adenocarcinoma

Shots:

  • The first patient has been dosed in a P-II study evaluating the safety & preliminary efficacy of onvansertib + Irinotecan and 5-FU in ~40 patients as a 2L treatment for metastatic PDAC who have failed 1L gemcitabine-based therapy across 6 sites in the US
  • The 1EPs of the study is ORR and 2EPs include DoR- m-OS- ORR in patients receiving more than two treatment cycles- DCS- and assessment of KRAS allelic burden in liquid biopsies as measured by ctDNA
  • The ongoing P-II trial of onvansertib + irinotecan and 5-FU for KRAS-mutated mCRC showed clinical benefit and improve outcomes. Additionally- the company is also expected the similar results in PDAC trial

  | Ref: PR Newswire | Image: Cardiff Oncology

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